A mast cell reaction involves the release of compounds by mast cells, which are immune cells. In prurigo nodularis (PN), mast cells release histamine and substance P, causing itching and pain. These compounds are part of the inflammatory process and can increase the number of fibroblasts, contributing to the symptoms of PN.

A mast cell reaction involves the release of compounds by mast cells, which are immune cells. In prurigo nodularis (PN), mast cells release histamine and substance P, causing itching and pain. These compounds are part of the inflammatory process and can increase the number of fibroblasts, contributing to the symptoms of PN.

Key points:
- Mast cells: Immune cells involved in inflammation.
- Compounds released: Histamine and substance P.
- Effects: Causes itching, pain, and increases fibroblasts.

For more detailed information, you can refer to the knowledge base provided.

 This AI-generated response comes from MyPrurigoTeam and other selected sources. It is not a substitute for medical advice. Always ask your doctor about specific health concerns.

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