I had my gall bladder removed a couple months ago. The PN has been getting worse by the week.

Gastroenterologist told me last week and again yesterday dysfunctional gallbladders or lack of them causes skin problems and unstoppable itching.

Mine was diagnosed about 3 years after the gall bladder was removed. Doubt there's any connection.

I had a cholecystectomy 11 yrs before the first symptoms of PN. Not many people know that gallstone formation increase after gallbladder removal so U can still have stone attacks, but for sure the bile which are produced by the liver cells will no longer be stored in the gallbladder (since its gone) and the bile will be drained to the small intestine 24/7 instead of at the time of a meal so there will be bile all the time in the gut. Bile is known to have bile acid in it, and bile acids are known to produce itch, for exampel in inflammatory bile duct disease. Maybe cholestyramine (Ursofalk), which binds bile acids can help to decrease the itching. This was a very interesting comment, Wendy from Spokane. It would be interesting to see how many of the patients in the "My prurigoTeam" who has had the gallbladder removed before PN appeared. We should do a study ! Next week I´m going to have my bloodtests done INCLUDING serum bile acids, and if the slightest above normal i will start with cholestyramine.

I had a lot of skin issues prior to my gall bladder being removed. I've always had IBS issues too before and after the gall bladder removal. That is a question I will ask my GI doc and Internist.