I had my gall bladder removed a couple months ago. The PN has been getting worse by the week.

Gastroenterologist told me last week and again yesterday dysfunctional gallbladders or lack of them causes skin problems and unstoppable itching.

I had a cholecystectomy 11 yrs before the first symptoms of PN. Not many people know that gallstone formation increase after gallbladder removal so U can still have stone attacks, but for sure the bile which are produced by the liver cells will no longer be stored in the gallbladder (since its gone) and the bile will be drained to the small intestine 24/7 instead of at the time of a meal so there will be bile all the time in the gut. Bile is known to have bile acid in it, and bile acids are known to produce itch, for exampel in inflammatory bile duct disease. Maybe cholestyramine (Ursofalk), which binds bile acids can help to decrease the itching. This was a very interesting comment, Wendy from Spokane. It would be interesting to see how many of the patients in the "My prurigoTeam" who has had the gallbladder removed before PN appeared. We should do a study ! Next week I´m going to have my bloodtests done INCLUDING serum bile acids, and if the slightest above normal i will start with cholestyramine.

My mom was living on imodium but no specific diagnosis until! She had had her gall bladder out and I came home one day to her in the hospital seriously ill. Scar tissue had slowly wrapped itself around her intestines. I asked if it shows on an mri, no specific answer but ask! We almost lost her!

I had gall bladder issues/surgery 44 years ago. I had my first nodule while lying (on my back) in the hospital for gallbladder issues for a week. (Back when they would hospitalize people that long). The nodule on my shoulder became so inflamed/infected from laying on it, got a softball size lump. I had to have it removed, drained and packed with gauze for weeks. That nodule has itched ever since. Honestly my nodules & gallbladder issues showed up @ the same time. It just took over 40 years to be diagnosed with PN.